Salacity – Disc Shelf http://disc-shelf.com/ Wed, 21 Jul 2021 23:33:01 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://disc-shelf.com/wp-content/uploads/2021/05/cropped-icon-32x32.png Salacity – Disc Shelf http://disc-shelf.com/ 32 32 Blueprint Medicines Submits New Supplementary Drug Application to FDA for AYVAKIT ™ (avapritinib) for the Treatment of Advanced Systemic Mastocytosis https://disc-shelf.com/blueprint-medicines-submits-new-supplementary-drug-application-to-fda-for-ayvakit-avapritinib-for-the-treatment-of-advanced-systemic-mastocytosis/ https://disc-shelf.com/blueprint-medicines-submits-new-supplementary-drug-application-to-fda-for-ayvakit-avapritinib-for-the-treatment-of-advanced-systemic-mastocytosis/#respond Sun, 28 Mar 2021 22:34:29 +0000 https://disc-shelf.com/blueprint-medicines-submits-new-supplementary-drug-application-to-fda-for-ayvakit-avapritinib-for-the-treatment-of-advanced-systemic-mastocytosis/ CAMBRIDGE, Mass., December 17, 2020 / PRNewswire / – Blueprint Medicines Corporation (NASDAQ: BPMC), a precision therapy company focused on genomically defined cancers, rare diseases and cancer immunotherapy, today announced the submission of a new drug application Supplement (sNDA) to the United States Food and Drug Administration. (FDA) for AYVAKIT ™ (avapritinib) for the treatment […]]]>

CAMBRIDGE, Mass., December 17, 2020 / PRNewswire / – Blueprint Medicines Corporation (NASDAQ: BPMC), a precision therapy company focused on genomically defined cancers, rare diseases and cancer immunotherapy, today announced the submission of a new drug application Supplement (sNDA) to the United States Food and Drug Administration. (FDA) for AYVAKIT ™ (avapritinib) for the treatment of adult patients with advanced systemic mastocytosis (MS). AYVAKIT is a potent and selective inhibitor of the D816V KIT mutant, the primary driver of MS, and is under development to treat advanced and non-advanced forms of the disease.

Blueprint Medicines has requested a priority review for this application, which, if granted, could result in a six-month review process. The FDA has a 60-day filing review period to determine if the sNDA is complete and acceptable for filing. The FDA has granted AYVAKIT Breakthrough Therapy designation for the treatment of advanced MS, including aggressive MS subtypes, MS with associated hematologic neoplasm and mast cell leukemia.

“Today’s submission is an important step towards our goal of bringing AYVAKIT to patients with advanced systemic mastocytosis, a rare, debilitating and potentially fatal disease,” said Fouad Namouni, MD, president, Research and Development. “Our application is based on an unprecedented clinical data set in this disease, which showed that patients receiving AYVAKIT had high overall response and complete remission rates, with prolonged survival, and the treatment was generally well tolerated. We look forward to working closely with the FDA during the review, as we seek to introduce the first precision therapy targeting the underlying cause of systemic mastocytosis. “

About SM

MS is a rare disease caused by the KIT D816V mutation. The uncontrolled proliferation and activation of mast cells results in chronic, severe and often unpredictable symptoms in patients across the spectrum of MS. The vast majority of those affected have non-advanced (indolent or smoldering) MS, with debilitating symptoms that have a profound negative impact on quality of life. A minority of patients have advanced MS, which encompasses a group of high-risk MS subtypes including aggressive MS, MS with associated hematologic neoplasia, and mast cell leukemia. In addition to symptoms of mast cell activation, advanced MS is associated with organ damage due to mast cell infiltration and poor overall survival.

Debilitating symptoms, including anaphylaxis, maculopapular rashes, pruritus, diarrhea, brain fog, fatigue, and bone pain, often persist in all forms of MS despite treatment with a number of symptomatic therapies. Patients often live in fear of severe and unexpected symptoms, have a limited ability to work or perform daily activities, or self-isolate to protect themselves from unpredictable triggers. Currently, there are no approved therapies for the treatment of MS that selectively inhibit the mutant KIT D816V.

About AYVAKIT (avapritinib)

AYVAKIT (avapritinib) is an FDA-approved kinase inhibitor for the treatment of adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) carrying a mutation in PDGFRA exon 18, including mutations of PDGFRA D842V. For more information visit www.AYVAKIT.com. This medicine is approved in Europe under the brand name AYVAKYT® for the treatment of adults with unresectable or metastatic GIST carrying the PDGFRA D842V mutation.

AYVAKIT / AYVAKYT is not approved for the treatment of any other indication, including SM, in the United States by the FDA or in Europe by the European Commission, or for any indication in any other jurisdiction by any other health authority.

Blueprint Medicines is developing AYVAKIT globally for the treatment of advanced and indolent MS.

Blueprint Medicines has entered into an exclusive collaboration and licensing agreement with CStone Pharmaceuticals for the development and commercialization of AYVAKIT in Mainland China, Hong Kong, Macao and Taiwan. Blueprint Medicines retains the development and commercial rights of AYVAKIT in the rest of the world.

About Blueprint Medicines

Blueprint Medicines is a precision therapy company dedicated to improving human health. With a focus on genomically defined cancers, rare diseases and cancer immunotherapy, we are developing transformational drugs rooted in our cutting edge expertise in protein kinases, which are proven drivers of disease. Our uniquely scalable and targeted approach enables the rapid design and development of new treatments and increases the chances of clinical success. We have two approved precision therapies and are currently advancing several investigational drugs in clinical and preclinical development, as well as a number of early stage research programs. For more information visit www.BlueprintMedicines.com and follow us on Twitter (@BlueprintMeds) and LinkedIn.

Caution Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding AYVAKIT’s development plans and timelines for SM advanced and non-advanced; plans and timelines for the commercialization of AYVAKIT for Advanced MS, if approved; the potential benefits of Blueprint Medicines’ current and future approved drugs or drug candidates in the treatment of patients, including expectations regarding the potential of AYVAKIT for the treatment of patients with MS; and the strategy, goals and anticipated milestones, business plans and direction of Blueprint Medicines. The words “aim”, “be able”, “will fly”, “could”, “would”, “should”, “expect”, “plan”, “anticipate”, “intend to”, ” believe “,” estimate “,” plan “,” project “,” potential “,” continue “,” target “and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these words. ‘identification. All forward-looking statements contained in this press release are based on the current expectations and beliefs of management and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to occur. differ materially from those expressed or implied by any forward-looking statement. the statements contained in this press release, including, without limitation, the risks and uncertainties relating to the impact of the COVID-19 pandemic on the activities, operations, strategy, objectives and planned milestones Blueprint Medicines, including ongoing and planned research and discovery of Blueprint Medicines activities, ability to conduct ongoing and planned clinical trials, clinical supply of current or future drug candidates, commercial supply of current or future approved products, and launch, marketing and sale of current or future approved products; the ability and plans of Blueprint Medicines to continue to build and maintain a business infrastructure and to successfully launch, market and sell current or future approved products; Blueprint Medicines’ ability to successfully expand the approved indications for AYVAKIT / AYVAKYT and GAVRETO ™ (pralsetinib) or obtain marketing authorization for AYVAKIT / AYVAKYT and GAVRETO in other geographies in the future; the delay of any ongoing or planned clinical trials or the development of current or future Blueprint Medicines drug candidates; Advancement by Blueprint Medicines of multiple early stage efforts; Blueprint Medicines’ ability to successfully demonstrate the safety and efficacy of its drug candidates and to obtain approval of its drug candidates on a timely basis, if at all; the preclinical and clinical results of Blueprint Medicines drug candidates, which may not support the further development of these drug candidates; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials; Blueprint Medicines’ ability to obtain, maintain and enforce patents and other intellectual property protections for AYVAKIT / AYVAKYT, GAVRETO or any drug candidate it develops; Blueprint Medicines’ ability to develop and market companion diagnostic tests for AYVAKIT / AYVAKYT, GAVRETO or any of its current and future drug candidates; and the success of Blueprint Medicines’ current and future collaborations, partnerships or licensing agreements. These and other risks and uncertainties are further described in the section entitled “Risk Factors” in the documents filed by Blueprint Medicines with the Securities and Exchange Commission (SEC), including the most recent annual report of Blueprint Medicines on Form 10-K, as completed by its most recent Quarterly Report on Form 10-Q and any other filings Blueprint Medicines has made or may make with the SEC in the future. All forward-looking statements contained in this press release represent the views of Blueprint Medicines only as of the date hereof and should not be construed as representing its views as of any later date. Except as required by law, Blueprint Medicines expressly disclaims any obligation to update any forward-looking statements.

Brands

Blueprint Medicines, AYVAKIT, AYVAKYT, GAVRETO and associated logos are registered trademarks of Blueprint Medicines Corporation.

SOURCE Blueprint Medicines Corporation

Related links

http://www.blueprintmedicines.com



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Raymond James: Villages Farms valued over $ 27 after full ownership of Sunfarms https://disc-shelf.com/raymond-james-villages-farms-valued-over-27-after-full-ownership-of-sunfarms/ https://disc-shelf.com/raymond-james-villages-farms-valued-over-27-after-full-ownership-of-sunfarms/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/raymond-james-villages-farms-valued-over-27-after-full-ownership-of-sunfarms/ Today, Raymond James analyst Rahul Sarugaser sent a note to investors on Village Farms (TSX: VFF) (NASDAQ: VFF), raising their 12-month price target to $ 14 from $ 11 and reiterating their Outperform 2 recommendation. The headline reads “4-5x Upside $ 5 to $ 17- $ 27 in PSF Acquisition Scenarios | Update the model. […]]]>


Today, Raymond James analyst Rahul Sarugaser sent a note to investors on Village Farms (TSX: VFF) (NASDAQ: VFF), raising their 12-month price target to $ 14 from $ 11 and reiterating their Outperform 2 recommendation. The headline reads “4-5x Upside $ 5 to $ 17- $ 27 in PSF Acquisition Scenarios | Update the model.

Rahul says Village Farms has set itself up to acquire an even larger controlling stake, if not a 100% stake, in the Pure SunFarms joint venture of which it currently owns 58.7%. Therefore, Rahul has been proactive and modeled this hypothetical acquisition and states that Village Farm is buying up to 41.3% of the company, it would cost them between $ 25 and $ 300 million.

Raymond James claims that Pure SunFarms will capture “13% of the Canadian adult use market share through 2024” which is then stated “as a baseline scenario, which in turn drives a potential price tag. of the VFF share of $ 17.00 ”. Raymond James then assumes that with this 100% ownership of Pure SunFarms, Village will be more motivated to achieve its goal of 20% market share in the Canadian cannabis market, which in turn allows the share price to rise. Village to achieve a hypothetical $ 27 per share. .

There are a lot of moving parts in this hypothetical situation and for this reason Sarugaser made a matrix to justify the valuation estimates. The matrix shows Village’s estimated share price for each additional 10% they own for every additional $ 25 million of shares they issue to pay for the purchase of Pure SunFarms.

There are then three different columns to capture 13%, 16% and 20% of the Canadian cannabis market as a whole. Below you can see the hypothetical matrix. As you can see in Sarugaser’s model, if Village Farms has to pay more than $ 100 million for the additional 41.3% property, the hypothetical Village share price will go as low as $ 12 to $ 19 per. share, rather than their much higher $ 17-27.

There are currently six analyst recommendations and price targets on Village Farms. All six analysts have buy ratings. The 12-month average price target is CA $ 14.96, with the highest target coming from Douglas Cooper of Beacon Securities with a price target of CA $ 28, an increase of 328%. The lowest target price is CAD $ 8 for Eric Des Lauriers of Craig Hallum, which is a 23% increase.


Information for this briefing was found through Sedar and Refinitiv. The author has no title or affiliation related to this organization. Not a buy or sell recommendation. Always do additional research and consult a professional before purchasing a title. The author does not hold any license.



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Sci-Fi Podcasts: 15 You Can Listen To Right Now https://disc-shelf.com/sci-fi-podcasts-15-you-can-listen-to-right-now/ https://disc-shelf.com/sci-fi-podcasts-15-you-can-listen-to-right-now/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/sci-fi-podcasts-15-you-can-listen-to-right-now/ This content contains affiliate links. When you buy through these links, we may earn an affiliate commission. Looking for your new favorite sci-fi podcasts? We have what you need. Science fiction is a genre that encompasses many types of themes and storylines. So, unsurprisingly, each sci-fi podcast on this list has a completely different angle […]]]>


This content contains affiliate links. When you buy through these links, we may earn an affiliate commission.

Looking for your new favorite sci-fi podcasts? We have what you need. Science fiction is a genre that encompasses many types of themes and storylines. So, unsurprisingly, each sci-fi podcast on this list has a completely different angle to covering the genre. Maybe these 15 sci-fi podcasts will be perfect for you, or maybe a few will become your new favorites. But anyway, the best part about all these sci-fi podcasts? There are a lot of episodes available to listen to right now.

I have divided this list into two categories. First, we have podcasts about science fiction. These are your podcasts where the hosts sit down and discuss different sci-fi topics. If you’re looking for fictional podcasts that tell a sci-fi story, head to the second half of this list where I share some of the best sci-fi audio dramas. Forward!

Science fiction podcasts

1. SFF Yeah!

This is Book Riot’s sci-fi and fantasy podcast. SFF Yeah! is a bimonthly podcast that covers the latest news from the sci-fi / fantasy literary world. And of course, hosts Sharifah and Jenn discuss a lot of sci-fi / fantasy books as well. Listener, are you worried that your TBR stack will explode because of too many good book recommendations? Enter at your own risk.

2. Hugos over there

This sci-fi podcast is dedicated to reading and reviewing Hugo’s award-winning books. Host Seth Heasley is a self-proclaimed book enthusiast who seeks to improve his “geek quotient” by browsing through a bunch of great sci-fi books. If you want to see which novels the series has covered so far and which ones it still intends to make, check out this handy dandy list. Seth has a different guest on each episode, which makes things interesting and invites a lot of new perspectives on the genre.

3. 372 pages we’ll never get back

From award-winning science fiction literature, we move on to … something else. In this podcast, hosts Conor Lastowka and Michael J. Nelson spend their time reading books they are sure to hate. Thought How did it happen? but for books instead of movies. And the majority of the books they choose are science fiction and / or fantasy.

4. Front flash

This podcast takes science fiction, looks ahead, and speculates how much could eventually turn into science fact. In each episode, host Rose Eveleth discusses a possible future scenario (or not if possible). Some examples of recent topics on the podcast: a future where you can travel in time; a future where China replaces the United States as a global superpower; a future where moms convinced the United States to shut down the Internet. The subjects are varied and fascinating.

5. Spectology: The Sci-Fi Book Club Podcast

Spectology is a science fiction book club but in podcast form. Each month, hosts Matt and Adrian choose a book of speculative fiction to read, and they discuss their feelings about the book and its themes on the podcast. They also do bonus episodes where they give other sci-fi recommendations. Recently they did an episode about their favorite sci-fi aliens.

6. The SFF audio podcast

SFF Audio is a website that was created to talk to the world about Sci-Fi / Fantasy audio content. Their podcast features sci-fi and fantasy discussions with contributors and other podcasters, bloggers, academics, and writers. The podcast has two types of episodes. The “READ EN TANT” episodes are those where they end the reading and discussion of a text. The “TOPIC” episodes feature a focused discussion of a narrow topic in SFF.

7. Sword and Laser

At Sword & Laser, hosts Veronique Belmont and Tom merritt choose a sci-fi or fantasy book each month to discuss the show. Their most recent book choice was This is how you lose the time war by Amal El-Mohtar and Max Gladstone. The show also includes interviews, sci-fi / fantasy news, and they even did an SFF March Madness medium.

8. Imaginary Worlds

Imaginary worlds is a bimonthly podcast hosted by Eric Molinsky. You might recognize Molinksy’s name from his work on NPR. On his podcast Imaginary worlds, Molinsky talks to novelists, screenwriters, comic book artists, filmmakers and game designers about the process of creating fictional worlds. Imaginary worlds also examines the role of the sci-fi fan in cultivating these make-believe worlds by adhering to the “reality” of science fiction.

9. New arrivals

Most of the aforementioned podcasts are hosted by self-proclaimed scholars. That’s not the case with the final podcast on this half of the list. Hostesses / actresses Lauren Lapkus and Nicole Byer have never seen Star wars and they don’t know anything about the movies or the culture surrounding the franchise. On this series they make their way through all of them Star wars content in order of release date. Each week, they are joined by a co-host who knows something about Star wars.

Science Fiction Podcasts: Audio Dramas

ten. Mission to Zyxx

Mission to Zyxx is an improvised sci-fi podcast created and performed by Jeremy Bent, Alden Ford, Allie Kokesh, Seth Lind, Winston Noel and Moujan Zolfaghari. These improvisers all met at New York’s Upright Citizens Brigade Theater, and on the podcast they each play a member of the Federated Alliance. Each episode features a special guest comedian who plays an inhabitant of the Zyxx Quadrant unlucky enough to meet the Federated Alliance team.

11. A world where

Make sure to listen to this one with headphones. A world where is a binaural radio drama series. Each episode imagines a different scenario in the near future and the consequences of contemporary issues on future events, such as climate change, capitalist excesses, and neoliberal apathy. These are stories of normal people living in a near future world that is not too different from ours.

12. Fall of Mars

At Fall of Mars, we follow a group of settlers who settle on Mars in 2047. Each episode continues the story from a different settler’s point of view. The cast of characters is carefully developed and well-played, and of course, we learn more and more about each as the series progresses. The colony is headed by Commander Jacki O’Rania and assisted by the colonial artificial intelligence unit ANDI.

13. The left right game

This is a brand new podcast that just launched in March of this year and has already been picked up by Amazon to become a TV series. Hopefully the show will also feature Tessa Thompson, the podcast’s lead actress. In the podcast, Thompson plays an idealistic young reporter trying to make a name for herself by following a group of paranormal explorers. Explorers have become obsessed with what is called the left / right game. But as the Journalist and Explorers delve deeper into the game world, they realize that they are way above their heads.

14. Wolf 359

It’s the only podcast on this list that’s already done, but this one is so good I had to include it anyway. And if you haven’t discovered this one yet, now is a great time to marathon the whole podcast. Wolf 359 is part a space adventure, part character drama, and part absurd sitcom. This is the story of Doug Eiffel who is stuck in a scientific study mission of indefinite duration, 7.8 light years from Earth. A strange little group of characters accompany him on this mission: the stern mission leader Minkowski, the mad science officer Hilbert, and the sentient of the Hephaestus stationent, often a malfunction of the HERA operating system. As the crew searches for alien life, they begin to realize that this mission is more important than they initially thought.

15. In the wires

Last but not least! Creators of Welcome to Night Vale come In the wires. This podcast is made up of stories from an alternate universe, told using found audio. Each season tells a different story, and four full seasons are currently available. The most recent season tells the story of a mother and daughter living in an anti-government commune living in a remote Scandinavian forest.


If you’re browsing all of these podcasts and need even more sci-fi / fantasy content, check out Book Riot’s sci-fi / fantasy corner on the internet. here.



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General Manager Brenda Barnette Sends Invitation to ‘Adults Only’ Events to Los Angeles Animal Services Staff Via City Email https://disc-shelf.com/general-manager-brenda-barnette-sends-invitation-to-adults-only-events-to-los-angeles-animal-services-staff-via-city-email/ https://disc-shelf.com/general-manager-brenda-barnette-sends-invitation-to-adults-only-events-to-los-angeles-animal-services-staff-via-city-email/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/general-manager-brenda-barnette-sends-invitation-to-adults-only-events-to-los-angeles-animal-services-staff-via-city-email/ “Single and want to meet other animal lovers, this is a chance for you!” “ This “luck” is described in the email sent below by JJ Rawlinson. (JJ Rawlinson, DVM, Senior Manager, Community Partnerships & Welfare Initiatives at Wallis Annenberg PetSpace.) CityWatch readers may recall that on August 21, Councilor Paul Koretz’s Staff and Animal […]]]>


“Single and want to meet other animal lovers, this is a chance for you!” “

This “luck” is described in the email sent below by JJ Rawlinson. (JJ Rawlinson, DVM, Senior Manager, Community Partnerships & Welfare Initiatives at Wallis Annenberg PetSpace.)

CityWatch readers may recall that on August 21, Councilor Paul Koretz’s Staff and Animal Welfare Committee approved a $ 100,000 donation to LA Animal Services from the Annenberg Foundation. GM Barnette said Annenberg also donated $ 50,000 in 2018.

Also, at this time, brightly colored flyers for Annenberg PetSpace events were included with renewal notices sent by LA Animal Services to dog license holders throughout the city of Los Angeles.

here is the mail by ‘JJ Rawlinson’, Transmitted toall-ani@lacity.org> ofbrenda.barnette@lacity.org> January 29, 2020:

Material: Please come share !!

Hello friends,

Can I ask you a favor for sharing these super cool adult-only events that we have coming up in the next two weeks with your staff?

The first is Must love dogs: a mixer for singles which is going to be super fun. Tito’s vodka, animal lovers and a whole bunch of yummy gifts and stuff. We strongly encourage [sic] that they might want to come as we have a great female / RSVP participation list so far! The event is LCBTQ [sic] included and we hope to increase the number of single men who responded to the event in order to spread the news accordingly. Here is the link for more details.

Then, on Valentine’s Day, our very own Donna Fernandes makes a [sic] cool talk about animal love, courtship and mating in the animal world called The mating game. It’s going to be super fun (I have to keep telling him to keep it PG !!). . . wine and refreshments included. There will be games and activities. Here is the link for that one.

Oh and finally, we’re having a Yappy Hour party tomorrow night. Free drinks, fun games, soccer and animal theme, lots of delicious food, photo ops and great company! Everyone come!

Let me know if you have any questions and please spread the word to us!

thank you,

not a word

HERE IS A DESCRIPTION OF THE EVENT ON THE WEB:

Must love dogs: a mixer for singles is a free speed-dating event for dog lovers at Wallis Annenberg PetSpace. The free event will take place on Thursday February 6 from 6 p.m. to 9 p.m. with a cocktail party and speed dating session available to all guests.

LAAS EMPLOYEES ‘SPREAD THE WORD’

Many LAAS employees have expressed their shock. Some said it was “totally inappropriate”. Some were angry, as it looked like Brenda Barnette was trying to encourage them to accept an invitation to a speed-date or hook-up party. Others said they were upset that the department general manager didn’t realize that many (or most) of his employees are married to families.

Others wondered why this event was specifically listed as “LGBTQ inclusive” because, if it’s just a “Singles Mixer” by Annenberg, why should it be mentioned?

(Note: While working in San Francisco as the Director of Program Development for the SPCA, Ms. Barnette also served as chair of the board of directors of the lesbian, gay, bisexual and transgender community center project, according to Friends of 1800.org.)

WAS IT “CYBER-HARASSMENT?” ”

Several called it “sexual harassment” because the ad was sent by their boss, knowing they would feel compelled to open it.

(Legal experts debate a legal concept known as the “captive public doctrine” – which takes into account the extent to which a person can flee, or is “captive” – ​​as the most viable theory for justify the regulation of cyber-harassment within the confines of the First Amendment.)

IS A WOMEN GM SUBJECT TO DIFFERENT CITY RULES THAN A MAN?

What the hell did LA Animal Services CEO Brenda Barnette think? If she was a man, LAPD Chief Michel Moore, or LA City Fire Chief Ralph Terrazas, or General Service Department General Manager Tony Royster, would she still have a job after sending that touching invitation? to all employees so that they meet at a “mixer for singles” “which, among its other seductions, announces first There will be Tito’s vodka?

Would the LA Times ignore Council Chairman Herb Wesson urging his staff to The mating game talk, where wine is provided, and they can apparently learn how animals engage in sexual arousal and copulation? (Animal mating is not romantic!)

Or, what if Ron Nichols, the male director general of the Department of Water and Electricity, sent an official email inviting his employees to an adults-only Yappy Hour party with free drinks, fun games, and soccer. . .good company? ”

DO YOU REMEMBER THE SEX-TOY ANDREW ADELMAN AFFAIR?

On September 23, 2009, LA Weekly wrote that Los Angeles County District Attorney’s Office Steve Cooley confirmed to LA Weekly that it was formally reviewing allegations of sex toy rape against a senior city official.

The article said the announcement followed a two-month investigation by Los Angeles Police into an alleged situation without actual evidence or eyewitnesses and a “he said, she said” case. However, Adelman “was forced to resign”. (On October 9, the LA Times wrote:

that prosecutors refused to press charges in this case.)

The alleged incident occurred when Adelman met a woman in a11 July pub crawl organized by a staff member for a member of the Los Angeles City Council,” according to LA Weekly.

This is a reminder of why city authorities should not encourage offsite social gatherings with alcohol.

ED BOKS AND ‘HOOTERS’

Former LA Animal Services CEO Ed Boks resigned shortly after public and political outrage criticizing him for simply agreeing to accept a donation from the “Hooters” restaurant chain that would be generated by a fundraiser funds for a bikini competition for the sterilization of pets in the city. The event was called “Hooters for Neuters,” and Hooters was a known donor to charities and animal shelters.

“It was certainly not my intention to offend anyone,” Boks said in a statement. A promotional flyer posted on the LAAS website first showed a woman in a bikini, then changed to a dog wearing a “Hooters for Neuters” t-shirt.

Criticism by city officials of the proposed event was seen as a major factor in Boks’ resignation in 2009. (Mayor Sam’s “Sister City” blog provides a lively discussion of the melee on “The city of sirens?”)

WILL CITY OFFICIALS IGNORE GM BARNETTE’S “INAPPROPRIATE” EMAIL?

There’s nothing wrong with a speed-dating night between animal lovers – if you like that sort of thing – but, shouldn’t GM Brenda Barnette, who is paid $ 314,000 per year to make informed decisions to be held accountable for better judgment and discretionary acts in the dissemination of sexual innuendo in the workplace?

(Phyllis M. Daugherty is a former City of Los Angeles employee and contributor to CityWatch.) Edited for CityWatch by Linda Abrams.



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Diversify your collections of class books? Avoid these 7 traps https://disc-shelf.com/diversify-your-collections-of-class-books-avoid-these-7-traps/ https://disc-shelf.com/diversify-your-collections-of-class-books-avoid-these-7-traps/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/diversify-your-collections-of-class-books-avoid-these-7-traps/ Intermediate level : Farah Rocks fifth grade by Susan Muaddi Darraj, Clean getaway by Nic Stone, Ways to make the sun by Renée Watson Young adult: A phoenix must first burn edited by Patrice Caldwell, Wicked fox by Kat Cho, With fire up by Elizabeth Acevedo Diversity at surface level In February, Barnes & Noble […]]]>


Intermediate level : Farah Rocks fifth grade by Susan Muaddi Darraj, Clean getaway by Nic Stone, Ways to make the sun by Renée Watson

Young adult: A phoenix must first burn edited by Patrice Caldwell, Wicked fox by Kat Cho, With fire up by Elizabeth Acevedo

Diversity at surface level

In February, Barnes & Noble canceled a plan release twelve classic novels with covers featuring protagonists in color after critics called the promotion “literary blackface.” In one live episode of “Book Friends Forever”Podcast, author-illustrator Grace Lin says it’s tempting for picture book creators to make a similar mistake. “I want to make sure that the (miscellaneous books) that are created are the ones that are not made just because people are saying ‘Ah, we need diversity! Let’s put some dark skin on this character! ‘ It’s very superficial and a little insulting, ”she said. By showing people from marginalized groups texture and uniqueness, books such as Lin’s Caldecott-Honor-winning A big moon cake for the little star can move classroom and library collections beyond symbolic diversity.

Picture books: Fry bread by Kevin Noble Maillard and illustrated by Juana Martinez-Neal, Crown: an ode to the fresh cut by Derrick Barnes and illustrated by Gordon C. James, The arabic quilt by Aya Khalil and illustrated by Anait Semirdzhyan

Intermediate level : The only black girls in town by Brandy Colbert, Jasmin Toguchi, Queen of Mochi by Debbi Michiko Florence, A pinch of trouble by Anna Meriano

Young adult: The bottom girl by Stacey Lee, Let me hear a rhyme by Tiffany D. Jackson, Intact hearts by Cynthia Leitich Smith

Ignore intersectionality

Three decades ago, a lawyer and civil rights activist Kimberle Williams Crenshaw coined the term “intersectionalityAs a way to examine how courts have failed to consider the overlapping forms of discrimination faced by black women. Today the term is used more widely refer to how race, class, gender, sexuality and other characteristics overlap and shape the experiences of individuals. “We like to think of people as one thing or the other when you can be Asian, gay, and an immigrant,” said Martin, a professor at the University of Washington. While ten years ago it was perhaps difficult to find books written by and about people whose identities lie at these types of intersections, it is less and less true, said Martin. . “You can find these books if you search. “

Picture books: When Aidan became a brother by Kyle Lukoff and illustrated by Kaylani Juanita, King for a day by Rukshana Khan and illustrated by Christine Krömer, IntersectionAllies: we make room for everyone by Chelsea Johnson, LaToya Council and Carolyn Choi and illustrated by Ashley Seil Smith

Intermediate level : Carry me by Jacqueline Woodson, Mia Lee walks through college by Melissa and Eva Shang, The bridge house by Padma Venkatraman

Young adult: Felix forever by Kacen Callender, It’s my brain in love by IW Gregorio, Animals by Akwaeke Emezi

Acolyte syndrome

Author Christina soontornvat was an adult the first time she saw someone like her on a shelf. While browsing a bookstore, she came across Millicent Min, genius girl by Lisa Yee, originally published in 2004. “I just remember being like ‘Oh my god, is that an Asian girl on the cover of a book all by herself? Not like the Baby-Sitters Club, like Claudie on the Baby-Sitters Club, where she is just one of the babysitters, ”Soontornvat said in a round table hosted by the Asian Authors Alliance in May. “It was one of those things where you didn’t even know what you wanted or what was missing until you saw it.” Like Soontornvat, many authors of color and Indigenous writers today say that they didn’t see themselves portrayed in books as children or when they did, the characters were sidekicks, stereotypes, or both. Through their own books, these authors offer portraits that center and celebrate children of many identities.

Picture books: Maybe something beautiful by F. Isabel Campoy and Theresa Howell, illustrated by Rafael López, The patchwork bike by Maxine Beneba Clarke and illustrated by Van T. Rudd, Niño fights the world by Yuyi Morales

Intermediate level : Sal and Gabi break the universe by Carlos Hernandez, Tristan Strong Drills A Hole In The Sky by Kwame Mbalia, Dactyl Hill Squad by Daniel José Older

Young adult: Not your sidekick by CB Lee, You should see me in a crown by Léa Johnson, Give me some truth by Eric Gansworth

Treat groups like monoliths

Author Padma venkatraman don’t mind being confused with the Pulitzer Prize winner Jhumpa Lahiri, but she doesn’t think they are alike. “We also do not all share, within a given group, the same points of view,” Venkatraman wrote in a blog post 2018. As Venkatraman wrote, diversifying the shelves doesn’t just mean ticking off a book for each census category: “It means listening – and learning – and loving – individual voices, which differ by race, gender, in each label. that can be used. to bring people together. College teacher and youth author Lisa Stringfellow said this idea is also important when it comes to recommending books to young readers. She cautioned against assuming that a student will relate to a book solely based on race or ethnicity. This error is played for humor in the graphic novel New kid by Jerry Craft, in a scene where a librarian pushes a gritty urban novel about a poor, fatherless protagonist about a black boy. As it turns out, the boy’s father is the CEO of a Fortune 500 company. “There is a need to know our students on a personal level and not see our student identities as monoliths,” Stringfellow said.

Picture books: Just like me by Vanessa Brantley-Newton, Under my hijab by Hena Khan and illustrated by Aaliya Jaleel, Black is a rainbow color by Angela Joy and illustrated Ekua Holmes

Intermediate level : So done by Paula Chase, Indian no more by Charlene Willing McManis with Traci Sorell, Once upon a time in Eid edited by SK Ali

Young adult: Black brother, black brother by Jewel Parker Rhodes, The henna wars by Adiba Jaigirdar, Pretty Black: Stories of Being Young and Black in America edited by Ibi Zoboi

Excluding #OwnVoices

In 2015, amid the growing push for more diversity in children’s books, Corrine Duvyis, author and co-founder of Disability at Kidlit website, suggested using the hashtag #OwnVoices “Recommending kidlit about various characters written by authors from this same diverse group. The goal, wrote Duyvis, was “not to discourage people from writing outside of their own experiences.” It is to uplift those who are often ignored. Duyvis’ idea took off in the publishing world, although it has took longer to reach school librarians. For Stringfellow, the writers of their own voices bring something to stories that “someone outside of this community, no matter how much they’ve researched, would never be able to fully grasp. This authenticity has a powerful effect, especially for students who share that identity, Stringfellow said. When you do readings in the classroom A crazy summer of Rita Williams-Garcia, for example, she stops to discuss with the students of the grandmother the characters who press their hair. These details might otherwise go unnoticed to her mostly white students, she said, but students of color enjoy the conversation because hair questions and comments are a great source of microaggressions at school. Martin said supporting self-voiced writers also signals those in the publishing industry – who are predominantly white, heterosexual, cisgender and non-disabled women – that there is an interest in stories beyond those that editors have generally been willing to come back financially.

Picture books: Hair love by Matthew A. Cherry and illustrated by Vashti Harrison, We are grateful: Otsaliheliga by Traci Sorell and illustrated by Frané Lessac, Saturday by Oge Mora

Intermediate level : Yellow butterfly by Thanhha Lai, Look both ways by Jason Reynolds, The moon inside by Aida Salazar

Young adult: Tear down by Brittney Morris, Not all boys are blue by George M. Johnson, When Dimple met Rishi by Sandhya Menon

Stop at text





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A Conversation with HBCU Football Analyst Jay Walker – The Undefeated https://disc-shelf.com/a-conversation-with-hbcu-football-analyst-jay-walker-the-undefeated/ https://disc-shelf.com/a-conversation-with-hbcu-football-analyst-jay-walker-the-undefeated/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/a-conversation-with-hbcu-football-analyst-jay-walker-the-undefeated/ Analysis This is a daily question-and-answer session with African American college football broadcasters and analysts during The Undefeated Fall TV Week. Howard University graduate Jay Walker is an ESPN college football analyst and a staple of the historically black college and university network coverage (The Undefeated is part of ESPN). He played quarterback for the […]]]>


Analysis This is a daily question-and-answer session with African American college football broadcasters and analysts during The Undefeated Fall TV Week.

Howard University graduate Jay Walker is an ESPN college football analyst and a staple of the historically black college and university network coverage (The Undefeated is part of ESPN). He played quarterback for the Bisons and was selected in the seventh round of the 1994 NFL Draft by the New England Patriots. Walker also played for the Minnesota Vikings and the Barcelona Dragons of the World Football League. These days, the California native splits his time between calling HBCU games and serve in the Maryland Delegate House – you can often find him on an airplane reading documents for the State Ways and Means Committee. Ahead of the Sept. 17 game between Howard and Hampton, Walker spoke about calling games, the need for more black announcers, and San Francisco 49ers quarterback Colin Kaepernick’s right as an American to take a stand. against racial injustice.

Broadcaster – but also state legislator. How to balance the roles?

It’s a pretty healthy balance – and politics for me is like sports. I’m back in the locker room. You’ve got a defensive lineman, an offensive lineman, wide receivers, you’re all trying to come together for the betterment of the team. But sometimes they think you need to make it run more, others think you need to run it more. Same thing with politics. My athletic background has helped me in my job as a state legislator.

Do you think there is value in broadcasters being former players?

There is. My biggest concern is that I think the old player is underutilized. There are some things that we know and can understand, that a guy who hasn’t played this sport doesn’t know. You can talk about a quarterback missing a pass, but until you’ve actually looked at a linebacker knowing you’re going to get hit and still throw the ball? Easier said than done. So there are a lot of niceties that I believe athletes bring to the table.

“My biggest concern is that I think the former player is underutilized.”

What’s the biggest difference between calling a game HBCU and calling a Power 5 game?

The amount of talk you have to do. When you make an HBCU game, sometimes you just won’t have the noise of the crowd to carry it, and no one likes to watch TV and there is nothing to say. But I took that and made it an advantage. I tell more stories. At HBCU, it doesn’t all have to depend on what you see on the pitch, the plays. This is what is happening in the rest of the stadium. Where was the tailgate? Where did you go to eat Who did you run into? What legends? The bigger games, you kind of let the game do the talking the most. While in an HBCU, in the booth, we try to create a little more atmosphere.

What is the best part of HBCU football?

These are not the groups like everyone says. The biggest part is seeing hungry guys. They have these big dreams – I was in their shoes. They want it and want to do it. At the end of the day, let’s not forget that you are looking at 100 African American men who are going to graduate from college, hopefully, and enter the workforce and be the next leaders of tomorrow. It is something that you can be proud of. You see the hunger there and the work that these coaches do to try to shape these young men.

Jemele Hill (l) and Jay Walker on the set of His & Hers.

Randy Sager / ESPN Images

How would you assess the state of representation of blacks in sports broadcasting?

Phew. We need more. Will he ever be perfect? Probably not. I know for play-by-play… there aren’t a lot of African-American play-by-play guys. So this is something that needs to be addressed. There’s a whole generation behind us who probably won’t have this conversation in 10 or 15 years, hopefully.

“At HBCU, it doesn’t necessarily depend on what you see on the pitch… It’s what happens in the rest of the stadium.”

What do you think is the next step for Kaepernick and the other NFL players who have taken a stand on the national anthem?

It’s time to see the results. If you just take a stand, people think it’s for publicity. It’s not going anywhere. But if you take the money and put it in a legal defense fund or deal with families who have been victimized because of some of the senseless crimes that he thinks to have been committed, then it will do a lot of harm. path. . I know in the locker room it’s probably like, ‘OK, we just stood there. We have taken a stand with you. What’s going to come out of it? At the moment, he is an activist. I think he has to become a resultist. Once you start to see results then I think we can judge if everything was for the right thing.

Do you think Kaepernick’s willingness to speak out could reverberate at the university level?

It must. I think it will change America. The University of Missouri football team, they started something last year. The Northwestern football team, they said they wanted to unionize so they could get paid. Grambling said they weren’t going to play a game because they didn’t like the way their athletes were treated. I think the key is that you have to be responsible for the platform that you have. Colin Kaepernick is in the NFL. He has a platform, which is about six years old. So he’s using the platform he currently has, which is unlikely to be any bigger than it is now for the rest of his life. I congratulate him on it. He knew what he was doing. Because if he was a former football player, he wouldn’t get that attention. But because he’s a current National Football League quarterback, he’s attracting attention. He knows it and he uses his platform, which every American has the right to do.

Aaron Dodson is a sports and culture writer at The Undefeated. He mainly writes about sneakers / clothing and hosts the platform’s “Sneaker Box” video series. During Michael Jordan’s two seasons playing for the Washington Wizards in the early 2000s, the Air Jordan 9 “Flint” sparked his passion for kicking.





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Aphria Inc. Expands 510 Vaping Offerings Across Its Portfolio of Award-Winning Adult Brands https://disc-shelf.com/aphria-inc-expands-510-vaping-offerings-across-its-portfolio-of-award-winning-adult-brands/ https://disc-shelf.com/aphria-inc-expands-510-vaping-offerings-across-its-portfolio-of-award-winning-adult-brands/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/aphria-inc-expands-510-vaping-offerings-across-its-portfolio-of-award-winning-adult-brands/ Each Aphria vaporizer is designed with a unique offering to meet the demands of a diverse consumer segment. Whether through limited exit options, like Solei’s Harvest frosted mint or through the company’s proprietary extraction processes, 510 vaporizers of all brands deliver high quality extract without cutting agents. “From day one, we have been committed to […]]]>


Each Aphria vaporizer is designed with a unique offering to meet the demands of a diverse consumer segment. Whether through limited exit options, like Solei’s Harvest frosted mint or through the company’s proprietary extraction processes, 510 vaporizers of all brands deliver high quality extract without cutting agents.

“From day one, we have been committed to strategically developing a portfolio of award-winning brands that resonates with Canadians, delivers exceptional patient and consumer experiences, and competes in the illicit market,” said Irwin D. Simon, Chief executive officer. “We believe the strength of our brands remains unmatched in the industry and we are excited to expand 510 vaporizers across our brand portfolio, including Broken Coast’s first 2.0 cannabis product. As a result, Aphria continues to win market share and become the category leader, and successfully increase our revenues from adult cannabis products by 184% in our last fiscal year, ”said Irwin D. Simon, Chief executive officer.

The vape category should represent up to 20% of sales for adult use in Canada.1 At present, the Company maintains its number one position in the adult use market in both Alberta and Ontario, two of the largest provinces in Canada. In the last three months (ended October 31, 2020) in Ontario, Aphria continued to occupy the number one position with over 20% market share, high margin vape category in retail and online channels.2.3

Mr. Simon continued, “One of the biggest opportunities for Aphria is to convert consumers from the existing $ 3.9 billion illicit market We have ambitious goals with plans in place to continue growing our market share nationwide, already increasing our revenue from adult cannabis products by 184% in our last fiscal year . Our key insights into consumer data and our understanding of our consumption preferences, along with our strong innovation pipeline, allow us to continue to introduce premium products, such as our 510 Vapes, which together with our superior quality , are a key driver of conversion. ”

The company also announced that RIFF, Good Supply and Broken Coast will launch higher volume vape offerings with 1g fillings in the coming months.

Solei

Solei continues to appeal to consumers with its Moments platform and the thoughtful expansion of its product offerings, such as its limited release of the new Harvest frosted mint 510 Vape, which is one of the first seasonal vapes on the market. Harvest frosted mint brings a unique touch to Solei’s portfolio and is now available in Ontario, Alberta and New Brunswick until quantities run out.

Broken Coast

Broken Coast is widely recognized for setting the standard for premium cannabis in Canada. Take advantage of exclusive cultivation practices, optimized for each cultivar, Broken Coast coaxes the ultimate expression of each plant. For the first time, Broken Coast introduced 510 vapes to its product offering, which will be available from december 2020 nationwide (except for Quebec) with the Stargazer, Headstash and Frost Monster strains. Broken Coast’s proprietary extraction process properly preserves strain-specific cannabis terpenes and is reintroduced into a high-quality THC extract.

RIFF

RIFF has expanded its offering by launching iconic duos such as Grand Daddy Purps x Sour Kush and Jean Guy x Super Lemon Haze in 510 Vape Cartridges and 510 Battery, which are available nationwide (except Quebec) and the 1g format to be launched nationally in the coming months (with the exception of Quebec). the RIFF The vape formulation is a combination of two unique strains using high quality THC distillate and cannabis terpenes extracted from the cannabis plant.

Good supply

from Canada number one vape brand since June of this year4. Good supply has expanded its line of best-selling 510 vapes. Known for its cannabis-inspired formulations, Good Supply builds on the success of Pineapple Express vape, which was the best-selling vape in Ontario since January 20205. Now available nationwide (except Quebec and Newfoundland), Good Supply will offer three new strains to its 510 Vape range, including Purple monkey, Tangie kush and white widow, in addition to extending Pineapple Express and Purple monkey in 1g 510 Vapes.

B! NGO

Launched in September this year, B! NGO enters Cannabis 2.0 with Mist! and Gross! 510 vapers. Like his flower offerings, B! NGO The vapes will be launched in a larger volume with 1g fillings and two unique flavor profiles, available nationwide (with the exception of Quebec) from december 2020.

We have a good thing growing

About Aphria inc.

Aphria Inc. is a leading global cannabis company driven by an unwavering commitment to our people, the planet, product quality and innovation. Based at Leamington, Ontario – the capital greenhouse of Canada – Aphria Inc. has set the standard for the low-cost production of high-quality, large-scale cannabis, grown in the most natural conditions possible. By focusing on untapped opportunities and leveraging the latest technology, Aphria Inc. is committed to bringing disruptive innovation to the global cannabis market. The company’s brand portfolio is founded on consumer insights researched by experts and designed to meet the needs of each consumer segment. Rooted in the multigenerational expertise of our founders in commercial agriculture, Aphria Inc. creates sustainable long-term shareholder value through a diverse approach to innovation, strategic partnerships and global expansion.

For more information visit: aphriainc.com

CAUTION REGARDING FORWARD-LOOKING STATEMENTS: Certain information contained in this press release constitutes forward-looking statements under applicable securities laws and is expressly qualified by this cautionary statement. All statements contained in this press release that are not statements of historical fact can be considered as forward-looking statements. Forward-looking statements are often identified by words such as “may”, “should”, “anticipate”, “expect”, “potential”, “believe”, “intend” or the negative of these terms. and similar expressions. Forward-looking statements contained in this press release include, but are not limited to, statements regarding the planned launch by Aphria of new brand offerings and product formats. Forward-looking statements are based on the opinions, estimates and perception of management’s trends and beliefs with respect to future events at the date the statements are made, and are subject to various risks and uncertainties. and other factors that could cause actual events or results to differ materially from those projected in forward-looking statements. Factors that may cause such differences include, but are not limited to, the risks associated with COVID-19 nationally and globally that could have a material adverse impact on Aphria’s business, operations and financial results, including disruptions in cultivation and processing, supply chains and sales. channels, as well as a deterioration in general economic conditions, including national and / or global recessions and government response to the COVID-19 pandemic with respect to retail store operations; general economic conditions; adverse industry events; marketing costs; loss of markets; future legislative and regulatory developments relating to cannabis or otherwise affecting Aphria’s business or its consumers in general; the inability to access sufficient capital from internal and external sources, and / or the inability to access sufficient capital on favorable terms; the cannabis industry in Canada usually; income tax and regulatory matters, including delays in issuing licenses; the sale and distribution of vapes; Aphria’s ability to meet its liquidity needs to fund its day-to-day operations; Aphria’s ability to execute its business strategies; competition; poor harvests; the safety of cannabis-derived products; currency and interest rate fluctuations.

Readers are cautioned that the foregoing list is not exhaustive and that they should carefully consider the various risks and uncertainties identified in the documents filed by the Company on SEDAR and EDGAR. Readers are further cautioned not to place undue reliance on forward-looking statements, as there can be no assurance that the plans, intentions or expectations upon which they are based will be achieved. This information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated.

The forward-looking statements included in this press release are made as of the date of this press release and the Company does not undertake to publicly update these forward-looking statements to reflect new information, subsequent events or otherwise, unless applicable securities do not require it. laws. Neither the TSX nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release.

__________________________

1 Aphria internal sales forecast

2 Canadian Perspectives Headphones

3 OCS sales data

4 Headset Canadian Insights (BC, AB, SK, ON retail stores) – June to September 2020

5 OCS sales data. Total sales Jan-Oct 2020

SOURCE Aphria inc.

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Dynavax Announces Exercise of Additional CpG 1018 Reservation Option to Produce 40 Million Doses of Valneva’s Inactivated and Adjuvanted COVID-19 Vaccine Candidate for the UK Government https://disc-shelf.com/dynavax-announces-exercise-of-additional-cpg-1018-reservation-option-to-produce-40-million-doses-of-valnevas-inactivated-and-adjuvanted-covid-19-vaccine-candidate-for-the-uk-government/ https://disc-shelf.com/dynavax-announces-exercise-of-additional-cpg-1018-reservation-option-to-produce-40-million-doses-of-valnevas-inactivated-and-adjuvanted-covid-19-vaccine-candidate-for-the-uk-government/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/dynavax-announces-exercise-of-additional-cpg-1018-reservation-option-to-produce-40-million-doses-of-valnevas-inactivated-and-adjuvanted-covid-19-vaccine-candidate-for-the-uk-government/ EMERYVILLE, California., February 1, 2021 / PRNewswire / – Dynavax Technologies Company (Nasdaq: DVAX), a biopharmaceutical company focused on the development and commercialization of novel vaccines, today announced Valneva SE informed him that the UK government has exercised its option to order an additional 40 million doses of the adjuvanted SARS-CoV-2 vaccine candidate from Valneva, […]]]>


EMERYVILLE, California., February 1, 2021 / PRNewswire / – Dynavax Technologies Company (Nasdaq: DVAX), a biopharmaceutical company focused on the development and commercialization of novel vaccines, today announced Valneva SE informed him that the UK government has exercised its option to order an additional 40 million doses of the adjuvanted SARS-CoV-2 vaccine candidate from Valneva, VLA2001. This option exercise triggers the reservation of additional quantities of Dynavax Advanced Adjuvant CpG 1018 to support the production of 40 million doses of Valneva’s SARS-CoV-2 adjuvanted vaccine candidate, VLA2001. As part of its contract with the British government, Valneva has now reserved for delivery in 2021 CpG 1018 in sufficient quantities to support the production of 100 million doses of VLA2001.

In September 2020, the companies announced a commercial partnership for the supply of Dynavax’s CpG 1018 adjuvant for use in VLA2001, to support Valneva’s agreement with the UK government to deliver up to 190 million doses of VLA2001 over a period of five years. Dynavax plans to supply CpG 1018 to produce up to 100 million doses of vaccine in 2021. Valneva has the option to purchase additional quantities of CpG 1018 to support production of an additional 90 million doses of VLA2001 through 2025 .

“Our commercial supply agreement with Valneva confirms our strategy of leveraging CpG 1018 as an advanced vaccine adjuvant for use in the development of safe and effective vaccines, including against COVID-19,” commented Ryan spencer, Chairman and CEO of Dynavax, “As part of this agreement, we are currently manufacturing, and expect to deliver, an adjuvant for 100 million doses of VLA2001 which would generate CpG 1018 sales of up to $ 230 million in 2021, subject to the delivery of materials and the continued success of the program. We believe the emerging portfolio of CpG 1018 opportunities has the potential to spur the next stage in Dynavax’s growth, adding to the substantial opportunity of HEPLISAV-B, our US FDA approved adult hepatitis B vaccine. . “

This commercial supply partnership follows the initial collaboration of Valneva and Dynavax to advance the development of the COVID-19 vaccine, announced in april 2020.

VLA2001 entered Phase 1/2 clinical studies in december 2020 and recently completed registration. Initial safety and immunogenicity data are awaited in April 2021.

About CpG 1018 Adjuvant
CpG 1018 is the adjuvant used in HEPLISAV-B® [Hepatitis B Vaccine (Recombinant), Adjuvanted], an adult hepatitis B vaccine approved by the United States Food and Drug Administration (FDA). Dynavax developed CpG 1018 to provide an enhanced vaccine immune response, which has been demonstrated in HEPLISAV-B. CpG 1018 provides well-developed technology and a large safety database, potentially accelerating the development and large-scale manufacture of a COVID-19 vaccine.

About Dynavax
Dynavax is a commercial-stage biopharmaceutical company that develops and markets new vaccines. The Company launched its first commercial product, HEPLISAV-B® [Hepatitis B Vaccine (Recombinant), Adjuvanted], in February 2018, following US FDA approval for the prevention of infections caused by all known subtypes of the hepatitis B virus in adults 18 years of age and older. Dynavax is also continuing the development of CpG 1018 as an advanced vaccine adjuvant through collaborations and research partnerships. Current collaborations focus on adjuvanted vaccines for COVID-19, pertussis and universal influenza. For more information visit www.dynavax.com and follow the company on LinkedIn.

Dynavax forward-looking statements
This press release contains “forward-looking” statements, including statements regarding the potential development of a COVID-19 vaccine containing CpG 1018 and the commercial sale of CpG 1018 for use in the vaccine. Actual results may differ materially from those presented in this press release due to the risks and uncertainties inherent in vaccine research and development, including timing for completion of development, results of clinical trials, if and when the vaccine containing CpG 1018 will be approved for use, if and when purchases of CpG 1018 will take place, and the ability to manufacture a sufficient supply to meet purchasing needs, as well as other risks detailed in section “Risk Factors” of our Annual Report on Form 10-K for the Year Ended December 31, 2019 as well as discussions of potential risks, uncertainties and other important factors in our other filings with the United States Securities and Exchange Commission. We assume no obligation to revise or update the information contained in this document to reflect events or circumstances in the future, even if new information becomes available. Information on the Dynavax website at www.dynavax.com is not incorporated by reference into our current periodic relationship with the SEC.

Dynavax contacts:
Nicole arndt, Senior Director, Investor Relations
[email protected]
510-665-7264

Derek cole, President
Investor Relations Consulting Solutions
[email protected]

SOURCE Dynavax Technologies

Related links

http://www.dynavax.com



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Great presentation for the Chetek fishing competition | Free News https://disc-shelf.com/great-presentation-for-the-chetek-fishing-competition-free-news/ https://disc-shelf.com/great-presentation-for-the-chetek-fishing-competition-free-news/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/great-presentation-for-the-chetek-fishing-competition-free-news/ Hundreds of ice fishermen were scattered around the Chetek Chain of Lakes for the 27th Annual Chetek Fire Department Adult and Child Ice Fishing Tournament on Saturday January 16. The weather conditions were relatively mild, resulting in a high turnout for the annual event. The contest took place on all six lakes in the Chetek […]]]>


Hundreds of ice fishermen were scattered around the Chetek Chain of Lakes for the 27th Annual Chetek Fire Department Adult and Child Ice Fishing Tournament on Saturday January 16. The weather conditions were relatively mild, resulting in a high turnout for the annual event.

The contest took place on all six lakes in the Chetek Range and once again landed during Wisconsin’s annual Free Fishing Weekend.

The winners of the Adult Divisions Fishing Awards were: Ron Broht (first place northern pike, 9.31 lb), Zach Zappa (second place pike, 9.27 lb), Ashtyn Waite (third place pike, 8 , 9 lb); Riley Toufar (walleye first row, 2.41 lb), Jena Florczak (walleye second row, 2.35 lb), Buck (no last name listed) (walleye third row, 2.2 lb); Cayden Gifford (first place bass, 3.25 lbs), Isaac Whiting (second place bass, 2.91 lbs), Roger Brooten (third place bass, 2.89 lbs); Ron Razim (1st place mare, 0.90 lbs), Meirk Phimet (2nd place arrowroot, 0.90 lbs), Olivia Koehler (3rd place arrowroot, 0.89 lbs); Nathan Postle (first place sunfish, 0.59 lb), Ron Razim (second place sunfish, 0.59 lb), Lance Hulholland (third place sunfish, 0.44 lb); Justin Madaus (first place pole, 0.94 lb), Ray York (second place pole, 0.87 lb) and Kathy VanHeldon (third place pole, 0.87 lb); Nate Faughn (Biggest Rough Fish / Dog, 9.06 lbs).

The competition winners in the children’s division were Nicholas Frank (first place northern pike, 9.54 lb), Ryder Hakseth (second place pike, 6.95 lb), Keith Hamilton (third place pike, 6, 16 lb); Janika Lenbom (walleye first row, 1.64 lbs), Nolan Lentz (walleye second row, 1.62 lb), Miles Morehead (walleye third row, 1.18 lb); Easton Schaaf (first place bass, 2.11 lbs); Brantley Knickerbocker (second bass, 2.07 lbs), Josie VanBeek (third bass, 2.06 lbs); Haden Goebel (first place, .67 lbs.; Colt Jenneman (second place crappie, .67 lbs.); Jake Bischel (third place crappie, .33 lbs.); Duke Lehto (first place crappie,. 57 lb), Kenton Pierce (second place crappie, 0.55 lbs), Brantley Knickerbocker (third place crappie, 0.55 lbs); Jaylen Sedarski (first place pole vault, 0.77 lbs), Aspen Marshall (second place pole vault, 0 , 69 lbs) and Kyle Jahr (third place pole vault, 0.62 lbs).

This year’s lucky winner of the 2021 Ranger 570 Side-by-Side Grand Prize draw was Mike Walters. Second place of $ 250 went to Nick Sweet, while Jordan Schaaf took third place of $ 100 and Mariah Miles took fourth place of $ 50.

The raffle winners were Don Sessions (CZ Drake Over / Under 20 gauge), Jessica Larson (Smith & Wesson AR-15), Brock Hamilton (Ruger LCP .380), Pete Pederson (Springfield Hellcat 9mm), Derek Frank ( Ruger Wrangler .22), Jeff Welle (Remington 783 .223), Josh VanBeek (Ruger AR-556) and Chad Nelson (Traeger Pellet Grill).



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How Autism Shapes Sibling Relationships | Spectrum https://disc-shelf.com/how-autism-shapes-sibling-relationships-spectrum/ https://disc-shelf.com/how-autism-shapes-sibling-relationships-spectrum/#respond Sun, 28 Mar 2021 22:34:28 +0000 https://disc-shelf.com/how-autism-shapes-sibling-relationships-spectrum/ Stop being the father: SSome autistic children require so much attention that their siblings get lost in the shuffle. “Their needs may be overlooked or need to take a back seat,” says Leedham. In a study published earlier this year, for example, a girl complained that her parents minimized his learning problems because they were […]]]>

Stop being the father:

SSome autistic children require so much attention that their siblings get lost in the shuffle. “Their needs may be overlooked or need to take a back seat,” says Leedham. In a study published earlier this year, for example, a girl complained that her parents minimized his learning problems because they were minors compared to the challenges of his brother. As a result, she was not diagnosed with dyslexia until she was 12 years old.

Siblings of children with autism do best when they have people in their life – parents, extended family, coaches, teachers or friends – who listen and appreciate them and who they know they can count on. for help. Tomeny and her colleagues found that children with autistic siblings who want and receive support have relatively few emotional and behavioral problems. On the other hand, children who say they don’t get the support they need have more problems, such as anger outbursts or feelings of fear or worry.

One thing adults can do to support typical children is to help them understand that the difficult behaviors of an autistic sibling are a function of brain wiring. “Around the age of 6, my mom explained everything about autism to me,” says Luciana Heresi, an 11-year-old girl from Orange County, California, whose 13-year-old brother Santi has autism. His mother showed him videos which explained that some people with autism spoke about it repeatedly. special interests. “When I was younger, I was like, ‘He already told me this, he already told me that.’ I thought he was doing it on purpose just to bother me, “Luciana said.” But now that I know, I’m like ‘Oh, okay, I get it.’ Like, I can cope with it because I know he’s autistic.

According to experts, siblings should be allowed to calibrate the relationship and not, for example, be required to act as impromptu tutors, babysitters or rule enforcement officials. Brett Aurin says he sometimes keeps an eye on his twin brother, but his parents try not to lean on him too much for help. They even sometimes tease that he “has to stop being the father,” he says.

When siblings take on responsibility for a sibling by choice, experts say, they are much less likely to feel resentful than if they were forced to. By the time she was in high school, Diaz kept track of her brother Daniel’s prescriptions and took her to his doctor’s appointments, not the mall. “I didn’t do the things a kid usually would do, but I didn’t feel like I missed anything because I was there for every step with Daniel,” Diaz says. “Something in our bond has been magical. My name was his first word. His first steps were towards me.

Specialized support programs can also help siblings with their own moods and behaviors. the Sibling Support Project, for example, runs groups called Trade fairs in communities in the United States and abroad for children ages 8 to 13 who have a sibling with a disability. “It’s an outlet, a place where they can talk about their experience, their thoughts and their feelings,” Holl says. “You can feel very lonely if you don’t know other people who are going through similar situations.”

The experience of having an autistic sibling is complex. A child may regret that his brother’s behaviors make family vacations impossible, but also feel pride when he learns to tie shoelaces at the age of 13. “The sibling experience is really a mixed bag,” Holl says. “Not everything is great or terrible. It’s kind of all of the above at one point. Experts stress that no one should feel guilty for not having a good relationship with their autistic sibling. “A part of [the stories] are excellent, and some of them are not. All are equally valid, ”says Shivers.

“Something in our bond has been magical. My name was his first word. His first steps were towards me. Abigail Diaz

Whether the relationship is close or problematic, children tend to “take on” the sensitivities and strengths of their autistic siblings. In the 2019 Sisters’ Survey, a young girl moaned that her parents kept trying to get her autistic brother to eat foods he didn’t like, even though it predictably ended in a seizure of anger. And Holl recalls a Sunday morning workshop filled with sleepy teens who came to life around the issue of unequal expectations. Many complained cheerfully that their parents underestimated the capabilities of their siblings. “I know he can empty the dishwasher,” one boy said of his brother, “because when our parents are not at home I ask him to do it. In fact, he likes it!

In recent years, experts have also begun to examine these relationships from the other side, soliciting the voices of siblings with autism. This new research reveals that people with autism often don’t see anything unusual about their sibling relationships. Whatever problems a typical sibling may encounter, they are not always obvious to the autistic sibling. “Disabled and non-disabled siblings don’t always agree on what’s going on in their relationship,” says Meltzer, who has led much of this work. “And we didn’t really know that until we both started talking to each other.”

This disconnection happened for brothers AJ and Jarrett Link. Their parents divorced when they were young and AJ, who was diagnosed with autism as an adult, helped raise Jarrett, who is four years younger. Jarrett remembers the awkwardness and silences that troubled him as a child. After the diagnosis of AJ, who is now 30 years old, everything just made more sense. “That explained a lot of things,” says Jarrett, who now feels comfortable with his brother’s need for time alone.

For his part, AJ was unaware that awkwardness existed. “It’s weird to think of how for me it was just a normal experience,” he says. “But for [Jarrett], it was a different experience where he didn’t really understand what was going on. The brothers appreciate each other’s strengths. AJ admires Jarrett’s emotional support, and Jarrett says that AJ, who graduated from law school this year, is the smartest person he knows: “If I could just try and do some of the things that it does on an intellectual level, I would be very well off.

A similar loyalty inspired Michelle Byamugisha to contact Rudin, the TV meteorologist, on behalf of her brother during the pandemic. And within an hour of pressing send, a custom video arrival. “Hey Mark B, it’s Steve. I’m so happy to know that you’ve been watching me for over a decade, ”he began. “I know things are a little different right now because so much is changing in our world, but we’re all going to go through this together.” After more reassuring words, Rudin concluded with an invitation: “I hope that one day, when things get better, you and your sister can come and visit me here at the station. I would love it.

As Mark B watched Rudin’s message on his mother’s smartphone, his brother Jeremy filmed his quietly delighted reaction. Michelle posted this video on Twitter, where he has been viewed over 64,000 times.



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